Compounded Tirzepatide
Dual GIP/GLP-1 Weight Loss Online

Tirzepatide is a dual GIP/GLP-1 receptor agonist that activates two hormonal pathways instead of one. This dual action may produce greater weight loss than semaglutide alone. Individual results vary and are not guaranteed.

Compounded tirzepatide is a compounded medication prepared by a licensed pharmacy for an individual patient when clinically appropriate. Through Open Water Rx, independent licensed medical providers may prescribe compounded tirzepatide through licensed compounding pharmacy partners only when clinically appropriate for the individual patient.

Compounded tirzepatide is prescribed when an independent licensed medical provider determines it is clinically appropriate for the individual patient, for example, when a patient requires a specific dosage strength, formulation, or delivery method not available in the commercially manufactured product, or when the patient has a documented clinical need that the commercial product cannot meet.

Compounding is not offered simply as a lower-cost alternative to commercially available GLP-1 products. Under FDA regulations, compounding is only legally permissible when there is a valid individual clinical reason. Your prescribing provider makes this determination independently, based solely on your health profile.

Compounded medications are not generic versions of brand-name medications.

Compounded tirzepatide is prepared by independent, licensed compounding pharmacies operating under Section 503A of the Federal Food, Drug, and Cosmetic Act. Open Water Rx does not manufacture, compound, or dispense medications.

In clinical trials with FDA-approved tirzepatide formulations, patients on the highest dose achieved significant weight loss over 72 weeks. Compounded tirzepatide has not undergone the same clinical trials. Results vary by individual, starting dose, and adherence.

Both are excellent options. Tirzepatide tends to produce greater weight loss and may be preferred for patients with higher BMI or type 2 diabetes. Semaglutide has a longer track record and may be preferred for patients who are sensitive to new medications. Your licensed medical provider will recommend the best option based on your health profile.

The most common side effects are gastrointestinal: nausea, mild stomach discomfort, constipation, and occasional diarrhea, especially during dose escalation. These typically subside as your body adjusts.

Important safety information: GLP-1 receptor agonists, including tirzepatide, cause thyroid C-cell tumors in rodents. It is unknown whether tirzepatide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans. Tirzepatide is contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).

Pancreatitis has been reported in patients treated with GLP-1 receptor agonists. Discontinue tirzepatide promptly if pancreatitis is suspected and do not restart if confirmed. Tirzepatide is not recommended in patients with a history of pancreatitis.

Your licensed medical provider will review all relevant risks and benefits with you before prescribing. This is not a complete list of side effects.

In most cases, no. Open Water Rx is telehealth. Complete your health evaluation online, a licensed medical provider reviews it, and your tirzepatide prescription ships to your address if prescribed. Shipping is included in your plan price. In most states, no webcam or live call is required — the clinician review is fully asynchronous. A small number of states require a brief phone or video call before prescribing. We will let you know if that applies to you. Available nationwide in all 50 states.

Semaglutide plans start at $169/month and tirzepatide plans start at $219/month. One monthly price includes provider review, medication (if prescribed), shipping (if prescribed), and ongoing support. Pricing and availability are subject to clinical appropriateness and regulatory change. Tirzepatide pricing covers the full care pathway including clinician review and shipping if prescribed.